BDBM50660069 CHEMBL6162644

SMILES CN(C(=O)N[C@@H]1COCC1(F)F)[C@H]1CCCOc2cnccc21

InChI Key InChIKey=QGNONZIYXCSRLT-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50660069   

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataKd:  39nMAssay Description:Binding affinity to human SARM1 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Rattus norvegicus)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataIC50: 226nMAssay Description:Inhibition of rat SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataIC50: 288nMAssay Description:Inhibition of human SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Mus musculus)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataIC50: 363nMAssay Description:Inhibition of mouse SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataIC50: 402nMAssay Description:Inhibition of human SARM1 expressed in human SH-SY5Y cells assessed as SARM1 P1a activity measured after 60 mins by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CD38 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed