BDBM50660687 CHEMBL6161140

SMILES COc1ccc(N(C(=O)Nc2c(C)cccc2C)c2ccnc(Nc3ccc(C4CCN(C)CC4)cc3)n2)c(OC)c1

InChI Key InChIKey=BQAMAVDXNHUKAE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50660687   

TargetSerine/threonine-protein kinase SIK1(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660687BDBM50660687(CHEMBL6161140)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human SIK1 (02 to 131) assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by microplate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660687BDBM50660687(CHEMBL6161140)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant full length human SIK2 assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by micropla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK3(Human)
Insilico Medicine Shanghai Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660687BDBM50660687(CHEMBL6161140)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human SIK3 assessed as luminescence signal using AMARAtide/ATP as substrate measured after 120 mins by microplate readerMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed