BDBM50660688 CHEMBL6133785

SMILES CNC(=O)c1cnc(Nc2ccc(C(=O)NC3CCC(Nc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cn2)cc1Nc1cccc(-c2ncc(F)cn2)c1OC

InChI Key InChIKey=NKSVQPQJZWJRLO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50660688   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660688BDBM50660688(CHEMBL6133785)
Affinity DataIC50: 1.20nMAssay Description:Displacement of fluorophore-labeled probe from TYK2 JH2 domain (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660688BDBM50660688(CHEMBL6133785)
Affinity DataIC50: 100nMAssay Description:Displacement of fluorophore-labeled probe from JAK1 JH2 domain (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660688BDBM50660688(CHEMBL6133785)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to JAK3 (unknown origin) by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660688BDBM50660688(CHEMBL6133785)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to JAK2 (unknown origin) by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660688BDBM50660688(CHEMBL6133785)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to JAK1 (unknown origin) by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660688BDBM50660688(CHEMBL6133785)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to TYK2 JH1 domain (unknown origin) by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed