BDBM50662058 CHEMBL6150945
SMILES COC(=O)[C@H]1C[C@@H](Oc2c(O)ccc3cc(-c4ccc(OC(F)F)c(OCC5CC5)c4)oc23)CN1
InChI Key InChIKey=SXBNIHHUQAPOCJ-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50662058
Affinity DataIC50: 5.30nMAssay Description:Inhibition of PDE4B1 (324 to 659 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of human PDE4D2 (86 to 413 residues) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubated with compo...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of PDE4A10 (290 to 622 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 747nMAssay Description:Inhibition of PDE4C1 (314 to 639 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubate...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of PDE10A2 (449 to 770 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubat...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 5.91E+3nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubate...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE8A1 (480 to 828 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubate...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubate...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Hainan University
Curated by ChEMBL
Hainan University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE1B2 (10 to 487 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) extracted from Escherichia coli BL21 cells using 3H-cAMP/3H-cGMP as substrate preincubate...More data for this Ligand-Target Pair