BDBM50664118 CHEMBL6161713

SMILES COc1ccc(CN2C3CC2CN(c2ccc(-c4nc(-c5cnn(C)c5)cc5ncccc45)cn2)C3)cc1F

InChI Key InChIKey=LOHWDSDRIGMGBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50664118   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664118BDBM50664118(CHEMBL6161713)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of RET V804L mutant (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664118BDBM50664118(CHEMBL6161713)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of RET M918T mutant (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664118BDBM50664118(CHEMBL6161713)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of wild type RET (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664118BDBM50664118(CHEMBL6161713)
Affinity DataIC50: 38nMAssay Description:Inhibition of RET G810R mutant (unknown origin) by FRET-based ZLyte kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed