BDBM50664837 CHEMBL6171423

SMILES COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3n2)cc1C(=O)Oc1ccccc1

InChI Key InChIKey=IKONUSTXITZHRM-UHFFFAOYSA-N

Data  1 KI  4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50664837   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Xi'an Jiaotong University

Curated by ChEMBL

LigandBDBM50664837(CHEMBL6171423)Copy SMILESCopy InChI

Affinity DataIC50: 0.270nMAssay Description:Inhibition of recombinant PI3Kdelta (unknown origin) using PIP2:3PS as substrate preincubated for 20 mins followed by ATP addition and measured after...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/6/2026
Entry Details
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Xi'an Jiaotong University

Curated by ChEMBL

LigandBDBM50664837(CHEMBL6171423)Copy SMILESCopy InChI

Affinity DataKi:  1.90nMAssay Description:Covalent inhibition of PI3Kdelta (unknown origin) using PIP2:3PS as substrate assessed as inhibition constant incubated upto 180 mins in presence of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/6/2026
Entry Details
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Xi'an Jiaotong University

Curated by ChEMBL

LigandBDBM50664837(CHEMBL6171423)Copy SMILESCopy InChI

Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant PI3Kgamma (unknown origin) using PIP2:3PS as substrate preincubated for 20 mins followed by ATP addition and measured after...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/6/2026
Entry Details
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Xi'an Jiaotong University

Curated by ChEMBL

LigandBDBM50664837(CHEMBL6171423)Copy SMILESCopy InChI

Affinity DataIC50: 203nMAssay Description:Inhibition of recombinant PI3Kbeta (unknown origin) using PIP2:3PS as substrate preincubated for 20 mins followed by ATP addition and measured after ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/6/2026
Entry Details
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Xi'an Jiaotong University

Curated by ChEMBL

LigandBDBM50664837(CHEMBL6171423)Copy SMILESCopy InChI

Affinity DataIC50: 611nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin) using PIP2:3PS as substrate preincubated for 20 mins followed by ATP addition and measured after...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/6/2026
Entry Details
Copy BDB DOIPubMed
Copy reaction URL