BDBM50665897 CHEMBL6175377

SMILES CCOC(=O)Cn1c2ccc(C)cc2c(=O)c2cc(OC)c(C)c(C)c21

InChI Key InChIKey=BGSVOROMEUZHGP-UHFFFAOYSA-N

Data  5 IC50  4 Kd  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50665897   

TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataKd:  4.10nMAssay Description:Binding affinity to His-tagged human STING CTD assessed as dissociation rate constant (Kd) by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataEC50:  200nMAssay Description:Potentiation of cGAMP-induced mouse STING pathway activation expressed in HEK293 cells assessed as cGAMP EC50 at 100 uM incubated for 48 hrs by QUANT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataEC50:  740nMAssay Description:Potentiation of cGAMP-induced human STING pathway activation expressed in HEK293 cells assessed as cGAMP EC50 at 100 uM incubated for 48 hrs by QUANT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataEC50:  900nMAssay Description:Potentiation of cGAMP-induced mouse STING pathway activation expressed in HEK293 cells assessed as cGAMP EC50 at 33 uM incubated for 48 hrs by QUANTI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataEC50:  1.02E+3nMAssay Description:Potentiation of cGAMP-induced human STING pathway activation expressed in HEK293 cells assessed as cGAMP EC50 at 33 uM incubated for 48 hrs by QUANTI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Mouse)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataIC50: 2.20E+3nMAssay Description:Binding affinity to wildtype mouse STING incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataIC50: 4.66E+3nMAssay Description:Binding affinity to wildtype human STING R232 variant incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataKd:  5.68E+3nMAssay Description:Binding affinity to His-tagged human STING H232 variant assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataIC50: 6.33E+3nMAssay Description:Binding affinity to His-tagged STING (unknown origin) incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataKd:  8.56E+3nMAssay Description:Binding affinity to His-tagged human STING CTD assessed as dissociation constant by MST analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataIC50: 8.92E+3nMAssay Description:Binding affinity to human STING AQ variant incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataIC50: 1.01E+4nMAssay Description:Binding affinity to human STING H232 variant incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataKd:  1.22E+4nMAssay Description:Binding affinity to His-tagged human STING CTD assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology & Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665897BDBM50665897(CHEMBL6175377)
Affinity DataEC50:  2.05E+4nMAssay Description:Potentiation of cGAMP-induced STING pathway activation in human THP1-Dual KI-hSTING-R232 cells incubated for 24 hrs in presence of 5 microg/ml cGAMP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed