BDBM50665972 CHEMBL6164800

SMILES COc1ccn2c(-c3cncc(N[C@H]4CNCC[C@@H]4F)n3)cnc2c1

InChI Key InChIKey=KMBQFOHQXYQBES-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50665972   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FLT3 (unknown origin) preincubated with compound for 20 mins followed by [33p-ATP] addition and measured after 120 mins by P81 filter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of NanoLuc-fused FLT3 D835Y mutant (unknown origin) transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 to 3 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IRAK4 (unknown origin) preincubated with compound for 20 mins followed by [33p-ATP] addition and measured after 120 mins by P81 filter-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 1nMAssay Description:Inhibition of NanoLuc-fused IRAK4 (unknown origin) transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 to 3 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 11nMAssay Description:Inhibition of IRAK1 (unknown origin) preincubated with compound for 20 mins followed by [33p-ATP] addition and measured after 120 mins by P81 filter-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 71nMAssay Description:Inhibition of NanoLuc-fused FLT3 (unknown origin) transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 to 3 mins in presence ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
National Center for Advancing Translational Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665972BDBM50665972(CHEMBL6164800)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed