BDBM50667181 CHEMBL6177627

SMILES COc1nc(-c2cccc(-c3ccccc3)c2C)ccc1CNCCCCCCC(=O)NO

InChI Key InChIKey=GDQSIPBQQXPVHF-UHFFFAOYSA-N

Data  5 IC50  4 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50667181   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataIC50: 27nMAssay Description:Inhibition of PD-1/PD-L1 (unknown origin) protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataKd:  55nMAssay Description:Binding affinity to C-terminal 6His-tagged recombinant mouse PD-L1 (1 to 238 residues) expressed in HEK293 cells assessed as dissociation constant by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Mouse)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataKd:  73nMAssay Description:Binding affinity to C-terminal 6His-tagged recombinant mouse PD-L1 (1 to 238 residues) expressed in HEK293 cells assessed as dissociation constant by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant GST-tagged human HDAC6 extracted from Sf9 insect cells using fluorogenic substrate incubated for 30 mins by fluorescence mi...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataKd:  179nMAssay Description:Binding affinity to recombinant human PD-L1 (1 to 238 residues) expressed in HEK293 cells assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProgrammed cell death 1 ligand 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataKd:  464nMAssay Description:Binding affinity to recombinant human PD-L1 (1 to 238 residues) expressed in HEK293 cells assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataEC50:  3.15E+3nMAssay Description:Inhibition of PD-1 (unknown origin) expressed in human Jurkat cells co-expressing luciferase reporter under the control of NFAT promoter interaction ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataIC50: 9.08E+3nMAssay Description:Inhibition of recombinant full-length human HDAC1 (1 to 482 residues) extracted from baculovirus expression system using Ac-Leu-Gly-Lys (Ac)-AMC as s...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant full length human HDAC8 extracted from baculovirus infected Sf9 insect cells preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Gannan Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667181BDBM50667181(CHEMBL6177627)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC7 (501 to 952 residues) extracted from baculovirus expression system using Ac-Leu-Gly-Lys (...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed