BDBM50668820 CHEMBL6190161

SMILES Nc1cc(-c2ccc3c(/C=C/c4ccc(CN5CCOCC5)c(F)c4)n[nH]c3c2)ccn1

InChI Key InChIKey=DGVCCTJURVYOEM-UHFFFAOYSA-N

Data  3 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50668820   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of His-tagged human recombinant FLT3 catalytic domain (564 to 958 residues) expressed in insect cells using ATP as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataKd:  0.230nMAssay Description:Binding affinity to human FLT3-ITD-D835Y mutant by KINOMEscan analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of GST/His-tagged human recombinant FLT3 ITD mutant (571 to 993 residues) expressed in baculovirus expression system using ATP as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human partial length FLT3 D835V mutant (592 to 969 residues) expressed in mammalian expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataKd:  0.310nMAssay Description:Binding affinity to human partial length FLT3 D835Y mutant (580 to 969 residues) expressed in bacterial expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataKd:  0.570nMAssay Description:Binding affinity to human partial length FLT3-ITD-F691L mutant expressed in mammalian expression system by KINOMEscan analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50668820BDBM50668820(CHEMBL6190161)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of FLT3 D835Y mutant (unknown origin) incubated for 120 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed