BDBM506722 N-(3-(4-fluorophenyl)- bicyclo[1.1.1]pentan-1-yl)- 2-((1R,3s,5S,6r)-3-((6- fluoroquinolin-4-yl)- oxy)bicyclo[3.1.0]hexan-6- yl)propanamide::US11046649, Ex. 100

SMILES C[C@H]1CCN1c1nc(N2C[C@@H]3[C@@H](CC(=O)O)[C@@H]3C2)c2ncsc2n1

InChI Key InChIKey=AODVCHVDRDXUSE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 506722   

TargetKetohexokinase(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506722BDBM506722(US12534477, Compound WX001)
Affinity DataIC50: 180nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 2D6(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506722BDBM506722(US12534477, Compound WX001)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 2C19(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506722BDBM506722(US12534477, Compound WX001)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 2C9(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506722BDBM506722(US12534477, Compound WX001)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 1A2(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506722BDBM506722(US12534477, Compound WX001)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 3A4(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506722BDBM506722(US12534477, Compound WX001)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent