BDBM506734 N-(5-(1H-1,2,4-triazol-1- yl)pyridin-2-yl)-2- cyclopropyl-2- ((1R,3s,5S,6r)-3-((6- fluoroquinolin-4-yl)oxy)- bicyclo[3.1.0]hexan-6- yl)acetamide::US11046649, Ex. 112

SMILES NS(=O)(=O)N1CCC2(CC1)[C@@H](c1cccc(-c3conc3C3CC3)n1)C2(F)F

InChI Key InChIKey=BMEPPUGWNLKADD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 506734   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 506734BDBM506734(US12534458, Example C2)
Affinity DataEC50:  850nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent