BDBM506737 2-((1R,3s,5S,6r)-3-((6- fluoroquinolin-4-yl)oxy)- bicyclo[3.1.0]hexan-6-yl)- N-(5-(trifluoromethyl)-1H- pyrazol-3-yl)butanamide::US11046649, Ex. 115

SMILES C[C@H]1CCN1c1nc(Nc2ccc(CC(=O)O)cc2)c2ccsc2n1

InChI Key InChIKey=OSTHFYIKKGAFEK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 506737   

TargetKetohexokinase(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506737BDBM506737(US12534477, Compound WX006)
Affinity DataIC50: 25nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 3A4(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506737BDBM506737(US12534477, Compound WX006)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 2D6(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506737BDBM506737(US12534477, Compound WX006)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 2C19(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506737BDBM506737(US12534477, Compound WX006)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 2C9(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506737BDBM506737(US12534477, Compound WX006)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent

TargetCytochrome P450 1A2(Human)
Hangzhou Zhongmeihuadong Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 506737BDBM506737(US12534477, Compound WX006)
Affinity DataIC50: 5.00E+4nMAssay Description:mGluR5 activity was determined in a cell-based assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2026
Entry Details US Patent