BDBM507872 7-chloro-1-(3-hydroxy-2- methylphenyl)-1,3-dihydroquinazoline- 2,4-dione::US11046691, Compound 110::US11084798, Cpd No 110::US11130759, Cpd. No. 110

SMILES Cc1c(O)cccc1-n1c2cc(Cl)ccc2c(=O)[nH]c1=O

InChI Key InChIKey=CEUJXAVZBLZHDZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 507872   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507872(7-chloro-1-(3-hydroxy-2- methylphenyl)-1,3-dihydro...)
Affinity DataIC50: <200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507872(7-chloro-1-(3-hydroxy-2- methylphenyl)-1,3-dihydro...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507872(7-chloro-1-(3-hydroxy-2- methylphenyl)-1,3-dihydro...)
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent