BDBM507896 4-[(2,2-difluoroethyl)amino]-1-phenyl- 7-(trifluoromethyl)hydroquinazolin-2- one::US11046691, Compound 119::US11084798, Cpd No 119::US11130759, Cpd. No. 119

SMILES FC(F)CNc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F

InChI Key InChIKey=VGCGDHLGCCEAMJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 507896   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507896(4-[(2,2-difluoroethyl)amino]-1-phenyl- 7-(trifluor...)
Affinity DataIC50: <200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507896(4-[(2,2-difluoroethyl)amino]-1-phenyl- 7-(trifluor...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507896(4-[(2,2-difluoroethyl)amino]-1-phenyl- 7-(trifluor...)
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent