BDBM507971 4-((3R)-3-hydroxypyrrolidinyl)-1- phenyl-7-(trifluoromethyl)hydro- quinazolin-2-one::US11046691, Compound 145::US11084798, Cpd No 145::US11130759, Cpd. No. 145
SMILES O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F
InChI Key InChIKey=FIVUQIUSDNJTFE-CQSZACIVSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 507971
Affinity DataIC50: <200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair