BDBM510571 US11078186, Example 25::US11078186, Example 95::rac-1-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-3-methylpyrrolidine-1-carbonyl)piperidin-1-yl)ethanone

SMILES CC(=O)N1CCC(CC1)C(=O)N1C[C@@H](c2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F)[C@](C)(C1)c1ccc(F)cc1

InChI Key InChIKey=PLEBLNIHUKCNPF-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 510571   

TargetNuclear receptor ROR-gamma [262-507](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510571(rac-1-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3...)
Affinity DataIC50: 108nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM510571(rac-1-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3...)
Affinity DataEC50:  143nMAssay Description:Inverse agonist activity at RORgammat (unknown origin) expressed in Jurkat cells by reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma [262-507](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510571(rac-1-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3...)
Affinity DataIC50: 311nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM510571(rac-1-(4-((3S,4S)-3-(4-fluorophenyl)-4-(4-(1,1,1,3...)
Affinity DataEC50:  1.08E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed