BDBM511218 2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3-ethynyl-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)-2-(thiazol-2-ylmethyl)malonic acid::US11078228, Example 142

SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2nccs2)(C(O)=O)C(O)=O)[C@](O)(C#C)[C@H]1O

InChI Key InChIKey=AJVSWIMPUDYPJA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511218   

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM511218(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 5nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM511218(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 5nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed