BDBM511311 1-(3-(7-Acetyl-1-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)azetidin-1-yl)ethan-1-one::US11058688, Example 12

SMILES CC(=O)N1CC(C1)c1nc(c2CN(CCn12)C(C)=O)-c1ccc2n(C)nc(-c3cnn(C)c3)c2c1

InChI Key InChIKey=OIKRVNKISWALQH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511311   

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511311BDBM511311(1-(3-(7-Acetyl-1-(1-methyl-3-(1-methyl-1H-pyrazol-...)
Affinity DataIC50: 341nMAssay Description:5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 511311BDBM511311(1-(3-(7-Acetyl-1-(1-methyl-3-(1-methyl-1H-pyrazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The binding of 2.5 nM of BRD4(49-170) to 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) was assessed following the same procedure described for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent