BDBM511558 US11059794, Example 6.18::tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfonylethyl]- piperidine-1-carboxylate (intermediate 16)/6-(2,2,2- trifluoroethoxy)-5- (trifluoromethyl)pyridine-3- carboxylic acid (CAS-RN 1588507- 32-7)

SMILES NS(=O)(=O)c1ccc(c(F)c1)S(=O)(=O)CCC1CCN(CC1)C(=O)c1cnc(OCC(F)(F)F)c(c1)C(F)(F)F

InChI Key InChIKey=BUPCUEOCEWPZKQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511558   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511558(tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfo...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
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TargetCarbonic anhydrase 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511558(tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfo...)
Affinity DataIC50: 12.9nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent