BDBM511563 US11059794, Example 6.23::tert-butyl 4-(2-fluoro-4- sulfamoylphenyl)sulfonylpiperidine- 1-carboxylate (intermediate 11)/6- cyclobutyloxy-5- cyclopropylpyridine-3-carboxylic acid (intermediate 17)

SMILES NS(=O)(=O)c1ccc(c(F)c1)S(=O)(=O)C1CCN(CC1)C(=O)c1cnc(OC2CCC2)c(c1)C1CC1

InChI Key InChIKey=OHJCFUHWDONOCM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511563   

TargetCarbonic anhydrase 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511563(tert-butyl 4-(2-fluoro-4- sulfamoylphenyl)sulfonyl...)
Affinity DataIC50: 2.90nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511563(tert-butyl 4-(2-fluoro-4- sulfamoylphenyl)sulfonyl...)
Affinity DataIC50: 4nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent