BDBM511573 US11059794, Example 6.33::tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfonylethyl]- piperidine-1-carboxylate (intermediate 16)/2-cyclopropyl-6- (oxan-4-ylmethoxy)pyridine-4- carboxylic acid (CAS-RN 1810776- 23-8)

SMILES NS(=O)(=O)c1ccc(c(F)c1)S(=O)(=O)CCC1CCN(CC1)C(=O)c1cc(OCC2CCOCC2)nc(c1)C1CC1

InChI Key InChIKey=LZXUVWUXKWKZOC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511573   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511573(tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfo...)
Affinity DataIC50: 3nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
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TargetCarbonic anhydrase 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511573(tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfo...)
Affinity DataIC50: 20nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent