BDBM513000 BDBM513003::US11091451, Compound I-50

SMILES OC(=O)CNC(=O)Cc1csc(n1)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=PTAOZOVTACTSEC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 513000   

TargetSerine hydroxymethyltransferase, mitochondrial [30-504](Human)
Raze Therapeutics

US Patent
LigandPNGBDBM513000(US11091451, Compound I-50 | BDBM513003)
Affinity DataIC50: 5.50E+4nMAssay Description:Full length human cytosolic Serine Hydroxymethyl transferase 1 (SHMT1, residues 1-483 in Uniport ID P34896) was expressed as an N-terminal His6 tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
Raze Therapeutics

US Patent
LigandPNGBDBM513000(US11091451, Compound I-50 | BDBM513003)
Affinity DataIC50: 2.00E+5nMAssay Description:Full length human cytosolic Serine Hydroxymethyl transferase 1 (SHMT1, residues 1-483 in Uniport ID P34896) was expressed as an N-terminal His6 tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetSerine hydroxymethyltransferase, mitochondrial [30-504](Human)
Raze Therapeutics

US Patent
LigandPNGBDBM513000(US11091451, Compound I-50 | BDBM513003)
Affinity DataIC50: 2.00E+5nMAssay Description:Full length human cytosolic Serine Hydroxymethyl transferase 1 (SHMT1, residues 1-483 in Uniport ID P34896) was expressed as an N-terminal His6 tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetSerine hydroxymethyltransferase, cytosolic(Human)
Raze Therapeutics

US Patent
LigandPNGBDBM513000(US11091451, Compound I-50 | BDBM513003)
Affinity DataIC50: 2.00E+5nMAssay Description:Full length human cytosolic Serine Hydroxymethyl transferase 1 (SHMT1, residues 1-483 in Uniport ID P34896) was expressed as an N-terminal His6 tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent