BDBM518049 8-(2-azabicyclo[2.2.1]heptane-2-carbonyl)-4-[(2R)-3-(3,4-dihydro-1H-isoquinolin-2-yl)- 2-hydroxy-propyl]-2,3-dihydro-1,4-benzoxazepin-5-one::US11111237, Example 188::US11725001, Example 188

SMILES O[C@H](CN1CCc2ccccc2C1)CN1CCOc2cc(ccc2C1=O)C(=O)N1CC2CCC1C2

InChI Key InChIKey=GFAFCVPKWQGEEC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518049   

TargetProtein arginine N-methyltransferase 5(Human)
Sk Biopharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 518049BDBM518049(US11111237, Example 188 | 8-(2-azabicyclo[2.2.1]he...)
Affinity DataIC50: 550nMAssay Description:Experimental procedure: The histone H4 peptide was diluted with carbonate-bicarbonate buffer and prepared to 100 μg/mL, and then dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Sk Biopharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 518049BDBM518049(US11111237, Example 188 | 8-(2-azabicyclo[2.2.1]he...)
Affinity DataIC50: 550nMAssay Description:The histone H4 peptide was diluted with carbonate-bicarbonate buffer and prepared to 100 μg/mL, and then dispensed onto the plate per 100 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent