BDBM518580 US11124523, Example (+)-18

SMILES Fc1cc(Cl)cc(CNCC[C@]2(CCO[C@]3(CCOC3)C2)c2ccccn2)c1

InChI Key InChIKey=ZFZLGDAGWBQDLP-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 518580   

TargetMu-type opioid receptor(Human)
TBA

US Patent
LigandPNGBDBM518580(US11124523, Example (+)-18)
Affinity DataEC50:  4.20nMAssay Description:The experiment was performed using a cAMP detection kit from Cisbio (Cisbio #62AM4PEJ).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetCytochrome P450 2D6(Human)
TBA

US Patent
LigandPNGBDBM518580(US11124523, Example (+)-18)
Affinity DataIC50: 2.45E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetCytochrome P450 1A2(Rat)
TBA

US Patent
LigandPNGBDBM518580(US11124523, Example (+)-18)
Affinity DataIC50: 5.00E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetCytochrome P450 2C9(Human)
TBA

US Patent
LigandPNGBDBM518580(US11124523, Example (+)-18)
Affinity DataIC50: 5.00E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetCytochrome P450 2C19(Human)
TBA

US Patent
LigandPNGBDBM518580(US11124523, Example (+)-18)
Affinity DataIC50: 5.00E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
TBA

US Patent
LigandPNGBDBM518580(US11124523, Example (+)-18)
Affinity DataIC50: 5.00E+4nMAssay Description:To test the inhibitory effects of the compounds of the present disclosure on different isoforms of human cytochrome P450 isoenzymesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent