BDBM523036 US11161854, Example 2.8-1::US11161854, Example 2.8-2

SMILES CNc1nc(cc(n1)-n1ncc2ccc(cc12)C1(CC11CC1)C#N)N1CC[C@@H](C1)C(F)F

InChI Key InChIKey=GHSITXUBGICRGR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 523036   

LigandPNGBDBM523036(US11161854, Example 2.8-1 | US11161854, Example 2....)
Affinity DataIC50: 0.700nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
US Patent

LigandPNGBDBM523036(US11161854, Example 2.8-1 | US11161854, Example 2....)
Affinity DataIC50: 1.10nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
US Patent