BDBM523901 2-amino-5-chloro-N-[1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidyl]-pyridine-4-carboxamide::US11136325, Compound 3

SMILES Cc1c[nH]c2ncnc(N3CCC(CC3)NC(=O)c3cc(N)ncc3Cl)c12

InChI Key InChIKey=ZLOBOPFIUGIVMK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 523901   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523901(US11136325, Compound 3 | 2-amino-5-chloro-N-[1-(5-...)
Affinity DataIC50: 2nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523901(US11136325, Compound 3 | 2-amino-5-chloro-N-[1-(5-...)
Affinity DataIC50: 8.91nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523901(US11136325, Compound 3 | 2-amino-5-chloro-N-[1-(5-...)
Affinity DataIC50: 15.8nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent