BDBM523902 2-amino-N-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidyl]pyridine-4-carboxamide::US11136325, Compound 4

SMILES Nc1cc(ccn1)C(=O)NC1CCN(CC1)c1ncnc2[nH]cc(Cl)c12

InChI Key InChIKey=GXPOETDGLYYIAQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 523902   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 0.398nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 3.47nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 6.31nMAssay Description:ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 6(Human)
Galapagos

US Patent
LigandPNGBDBM523902(US11136325, Compound 4 | 2-amino-N-[1-(5-chloro-7H...)
Affinity DataIC50: 6.46nMAssay Description:IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent