BDBM525986 5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroisoquinolin-8-yl)amino)-N-(thiazol-2-yl)benzenesulfonamide 2,2,2-trifluoroacetate::US11174268, Example 93

SMILES Fc1cc(NC2CCCc3ccncc23)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=ZENFAJIAXHLNGU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525986   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525986(5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroisoquinoli...)
Affinity DataIC50: 270nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525986(5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroisoquinoli...)
Affinity DataIC50: 314nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525986(5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroisoquinoli...)
Affinity DataIC50: 8.47E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent