BDBM526597 (E)-N-(3-(((8-isopropyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrazolo[1,5-a] [1,3,5]triazin-4-yl)amino)methyl)phenyl)-1-(4-methoxybut-2-enoyl)pyrrolidine-3- carboxamide::US11186576, Compound 68.

SMILES COC\C=C\C(=O)N1CCC(C1)C(=O)Nc1cccc(CNc2nc(NC3CCOCC3)nc3c(cnn23)C(C)C)c1

InChI Key InChIKey=SDHIXASQHYFOME-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526597   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 526597BDBM526597((E)-N-(3-(((8-isopropyl-2-((tetrahydro-2H-pyran-4-...)
Affinity DataIC50: 650nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent