BDBM526666 1-acryloyl-N-(3-(((3-isopropyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazolo[1,5- a]pyrimidin-7-yl)amino)methyl)phenyl)azetidine-2-carboxamide::US11186576, Compound 139.

SMILES CC(C)c1cnn2c(NCc3cccc(NC(=O)C4CCN4C(=O)C=C)c3)cc(NC3CCOCC3)nc12

InChI Key InChIKey=OPJYPQHGSWFBRW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 526666   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM526666(1-acryloyl-N-(3-(((3-isopropyl-5-((tetrahydro-2H-p...)
Affinity DataIC50: <300nMAssay Description:The ability of compounds to inhibit CDK7 kinase activity was tested in a TR-FRET assay using 5 nM of CDK7/CycH/MNAT1 obtained from Invitrogen, USA. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent