BDBM528046 US11180482, Example I-27

SMILES COc1cc2CCN(C)Cc2cc1Nc1ncc(c(Nc2ccccc2P(C)(C)=O)n1)C(F)(F)F

InChI Key InChIKey=ZXCLJAYBOJECIX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 528046   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM528046(US11180482, Example I-27)
Affinity DataIC50: 5nMAssay Description:Inhibition of HPK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM528046(US11180482, Example I-27)
Affinity DataIC50: 7.5nMAssay Description:The enzymatic activity of Wild Type HPK1 (MAP4K1) Kinase was measured in the presence or absence of an inhibitor compound of the present disclosure b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent