BDBM531059 (R)-N1-(pyrrolidin-3-yl)-3-(2H-tetrazol-5-yl)-4-(2-thioxoimidazolidin-1-yl)benzene-1,2-disulfonamide::US11207312, Example 191

SMILES NS(=O)(=O)c1c(ccc(N2CCNC2=S)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1

InChI Key InChIKey=ZRUAEBYNEXTDST-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 531059   

TargetVIM-1 metallo-beta-lactamase(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531059(US11207312, Example 191 | (R)-N1-(pyrrolidin-3-yl)...)
Affinity DataIC50: 0.210nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531059(US11207312, Example 191 | (R)-N1-(pyrrolidin-3-yl)...)
Affinity DataIC50: 0.940nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531059(US11207312, Example 191 | (R)-N1-(pyrrolidin-3-yl)...)
Affinity DataIC50: 1.15nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531059(US11207312, Example 191 | (R)-N1-(pyrrolidin-3-yl)...)
Affinity DataIC50: 25.2nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent