BDBM531281 3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)- 2-methylpyridine 1-oxide::US11207325, Example 204

SMILES Cc1nc(NCc2c(F)ccc3c2CCO3)n2cnnc2c1-c1ccc[n+]([O-])c1C

InChI Key InChIKey=UPEGVYPQHFPRNW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 531281   

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531281BDBM531281(US11207325, Example 204 | 3-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 10.3nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531281BDBM531281(US11207325, Example 204 | 3-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 10.6nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531281BDBM531281(US11207325, Example 204 | 3-(5-(((5-fluoro-2,3-dih...)
Affinity DataIC50: 19.3nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent