BDBM535138 (3R)-3-(4-Chlorophenyl)-4-fluoro-3- ({1- [hydroxy(2H2)methyl]cyclopropyl}(2H2) methoxy)-6-(2-hydroxypropan-2-yl)-2- [(6-methylpyridazin-3-yl)methyl]-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 12::US11236047, Example 13::US20230338337, Example 13

SMILES CN(C)CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=FLSKRFKVCWLISS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 535138   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535138BDBM535138(US11236047, Example 13 | (3R)-3-(4-Chlorophenyl)-4...)
Affinity DataIC50: 5.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535138BDBM535138(US11236047, Example 13 | (3R)-3-(4-Chlorophenyl)-4...)
Affinity DataIC50: 5.80nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535138BDBM535138(US11236047, Example 13 | (3R)-3-(4-Chlorophenyl)-4...)
Affinity DataIC50: 7.70nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535138BDBM535138(US11236047, Example 13 | (3R)-3-(4-Chlorophenyl)-4...)
Affinity DataIC50: 46nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535138BDBM535138(US11236047, Example 13 | (3R)-3-(4-Chlorophenyl)-4...)
Affinity DataIC50: 120nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535138BDBM535138(US11236047, Example 13 | (3R)-3-(4-Chlorophenyl)-4...)
Affinity DataIC50: 120nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent