BDBM535163 4-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 1-({1- [hydroxy(2H2)methyl]cyclopropyl}(2H2) methoxy)-5-(2-hydroxypropan-2- yl)-3-oxo-2,3-dihydro-1H-isoindol-2- yl]methyl}benzonitrile::US11236047, Example 24

SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=DIVMTXBUDOMYFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535163   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535163BDBM535163(4-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 1-({1- [hydr...)
Affinity DataIC50: 7.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535163BDBM535163(4-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 1-({1- [hydr...)
Affinity DataIC50: 7.70nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent