BDBM535231 3-{[(1R)-1-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-5-(2- hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-1-yl]oxy}-1lambda6- thiolane-1,1-dione-Isomer 1::US11236047, Example 61::US11236047, Example 62

SMILES CS(=O)c1cc(Cl)ccc1CN1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)C(C)(C)O

InChI Key InChIKey=PVRYETGYPNIACM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 535231   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535231BDBM535231(3-{[(1R)-1-(4-Chlorophenyl)-2-[(5- chloropyridin-2...)
Affinity DataIC50: 2.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535231BDBM535231(3-{[(1R)-1-(4-Chlorophenyl)-2-[(5- chloropyridin-2...)
Affinity DataIC50: 16nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535231BDBM535231(3-{[(1R)-1-(4-Chlorophenyl)-2-[(5- chloropyridin-2...)
Affinity DataIC50: 41nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535231BDBM535231(3-{[(1R)-1-(4-Chlorophenyl)-2-[(5- chloropyridin-2...)
Affinity DataIC50: 110nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent