BDBM535234 (3R)-3-[(1-acetylazetidin-3- yl)methoxy]-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-6-(2- hydroxypropan-2-yl)-2,3-dihydro-1H- isoindol-1-one::US11236047, Example 63::US11236047, Example 64::US20230338337, Example 64

SMILES COCC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=XPPOSVDBYKUPEU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 535234   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535234BDBM535234((3R)-3-[(1-acetylazetidin-3- yl)methoxy]-3-(4-chlo...)
Affinity DataIC50: 2.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535234BDBM535234((3R)-3-[(1-acetylazetidin-3- yl)methoxy]-3-(4-chlo...)
Affinity DataIC50: 2.10nMAssay Description:Each assay was performed in a final volume of 15 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535234BDBM535234((3R)-3-[(1-acetylazetidin-3- yl)methoxy]-3-(4-chlo...)
Affinity DataIC50: 32nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535234BDBM535234((3R)-3-[(1-acetylazetidin-3- yl)methoxy]-3-(4-chlo...)
Affinity DataIC50: 40nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent