BDBM535262 1-({[(1R)-5-[1-(4-Acetylpiperazin-1- yl)-2-hydroxypropan-2-yl]-1-(4- chlorophenyl)-2-[(5-chloropyridin-2- yl)methyl]-7-fluoro-3-oxo-2,3-dihydro- 1H-isoindol-1- yl]oxy}methyl)cyclopropane-1- carboxamide::US11236047, Example 127::US11236047, Example 128

SMILES CCC(O)(c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1)c1ccccn1

InChI Key InChIKey=KHSRSNYUTBONQS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535262   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535262BDBM535262(1-({[(1R)-5-[1-(4-Acetylpiperazin-1- yl)-2-hydroxy...)
Affinity DataIC50: 4.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535262BDBM535262(1-({[(1R)-5-[1-(4-Acetylpiperazin-1- yl)-2-hydroxy...)
Affinity DataIC50: 110nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent