BDBM535282 2-(5-chloro-2-{[(1R)-1-(4- chlorophenyl)-7-fluoro-5-[(1S)-1- hydroxy-1-(oxan-4-yl)propyl]-1- methoxy-3-oxo-2,3-dihydro-1H- isoindol-2-yl]methyl}phenyl)acetic acid (tris(hydroxymethyl)aminomethane salt)::US11236047, Example 122

SMILES CC[C@](O)(C1CCOCC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3CC([O-])=O)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=KSQHEVCOEVTEOI-UHFFFAOYSA-M

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535282   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535282BDBM535282(2-(5-chloro-2-{[(1R)-1-(4- chlorophenyl)-7-fluoro-...)
Affinity DataIC50: 33nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent