BDBM535286 (3S)-3-(4-chlorophenyl)-3-[(1R)-1- (4-chlorophenyl)-7-fluoro-5-[(1S)-1- hydroxy-1-(oxan-4-yl)propyl]-1- methoxy-3-oxo-2,3-dihydro-1H- isoindol-2-yl]propanoic acid::US11236047, Example 105

SMILES CC[C@](O)(C1CCOCC1)c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=TXTARTLLGHDDSD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535286   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535286BDBM535286((3S)-3-(4-chlorophenyl)-3-[(1R)-1- (4-chlorophenyl...)
Affinity DataIC50: 15nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent