BDBM535321 (3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-6-[2- hydroxy-1-(2-oxopyrrolidin-1- yl)propan-2-yl]-3-methoxy-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 257

SMILES CO[C@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(ccc12)C(C)(O)CN1CCCC1=O)c1ccc(Cl)cc1

InChI Key InChIKey=LEGWQUAVGNVBCC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535321   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535321BDBM535321((3R)-3-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)...)
Affinity DataIC50: 120nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent