BDBM535327 6-[(1S)-1-[(1R)-1-(4-Chlorophenyl)-7- fluoro-1-{[1- (hydroxymethyl)cyclopropyl]methoxy}- 5-(2-hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-2- yl]ethyl]pyridine-3-carbonitrile::US11236047, Example 169::US20230338337, Compound 169

SMILES C[C@H](N1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)C(C)(C)O)c1ccc(cn1)C#N

InChI Key InChIKey=ZTHJYOMAEPHLCZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535327   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535327BDBM535327(6-[(1S)-1-[(1R)-1-(4-Chlorophenyl)-7- fluoro-1-{[1...)
Affinity DataIC50: 4.60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535327BDBM535327(6-[(1S)-1-[(1R)-1-(4-Chlorophenyl)-7- fluoro-1-{[1...)
Affinity DataIC50: 4.60nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent