BDBM535361 6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy-1-(1-methylpiperidin-4- yl)ethyl]-1-{[1- (hydroxymethyl)cyclopropyl]methoxy}- 3-oxo-2,3-dihydro-1H-isoindol-2- yl]methyl}pyridine-3-carbonitrile Ex. 287 is the faster eluting isomer::US11236047, Example 287::US11236047, Example 288::US20230338337, Compound 288
SMILES CN1CCC(CC1)C(C)(O)c1cc2C(=O)N(Cc3ccc(cn3)C#N)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1
InChI Key InChIKey=FDQSEIVSQMEFMB-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 535361
Affinity DataIC50: 3.10nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair