BDBM535390 (3R)-6-[1-(1-acetylpiperidin-4-yl)-1- hydroxyethyl]-3-(4-chlorophenyl)-2- [(5-chloropyridin-2-yl)methyl]-4-fluoro- 3-methoxy-2,3-dihydro-1H-isoindol-1- one Ex. 293 is the slower eluting isomer::US11236047, Example 293

SMILES CO[C@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(cc(F)c12)C(C)(O)C1CCN(CC1)C(C)=N)c1ccc(Cl)cc1

InChI Key InChIKey=VGACYBQLPGODGA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535390   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535390BDBM535390((3R)-6-[1-(1-acetylpiperidin-4-yl)-1- hydroxyethyl...)
Affinity DataIC50: 1.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent