BDBM535400 2-{[1-({[(1R)-1-(4-Chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-7-fluoro-5- (2-hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-1- yl]oxy}methyl)cyclopropyl]methoxy} acetic acid::US11236047, Example 144

SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cn3)[C@](OCC3(COCC(O)=O)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=GOUTYWNJSCUIGZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535400   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535400BDBM535400(2-{[1-({[(1R)-1-(4-Chlorophenyl)-2-[(5- chloropyri...)
Affinity DataIC50: 2.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent