BDBM535410 1-({[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy-1-(1-methyl-1H-pyrazol- 4-yl)ethyl]-2-[(6-methoxypyridin-3- yl)methyl]-3-oxo-2,3-dihydro-1H- isoindol-1- yl]oxy}methyl)cyclopropane-1- carboxamide::US11236047, Example 216

SMILES COc1ccc(CN2C(=O)c3cc(cc(F)c3[C@]2(OCC2(CC2)C(N)=O)c2ccc(Cl)cc2)C(C)(O)c2cnn(C)c2)cn1

InChI Key InChIKey=QAJDMQMVZQWDGC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535410   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535410BDBM535410(1-({[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydrox...)
Affinity DataIC50: 3.20nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent