BDBM535435 6-{[(1R)-5-[1-(1-acetylpiperidin-4-yl)- 1-hydroxyethyl]-1-(4-chlorophenyl)-7- fluoro-1-methoxy-3-oxo-2,3-dihydro- 1H-isoindol-2-yl]methyl}pyridine-3- carbonitrile Ex. 297 is the slower eluting isomer::US11236047, Example 297::US20230338337, Compound 297

SMILES CO[C@]1(N(Cc2ccc(cn2)C#N)C(=O)c2cc(cc(F)c12)C(C)(O)C1CCN(CC1)C(C)=O)c1ccc(Cl)cc1

InChI Key InChIKey=UTHIKBCDDXKGAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535435   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535435BDBM535435(6-{[(1R)-5-[1-(1-acetylpiperidin-4-yl)- 1-hydroxye...)
Affinity DataIC50: 2.60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535435BDBM535435(6-{[(1R)-5-[1-(1-acetylpiperidin-4-yl)- 1-hydroxye...)
Affinity DataIC50: 2.60nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent