BDBM535453 (3R)-2-[(5-chloro-1-oxo-1lambda5-pyridin-2- yl)methyl]-3-(4-chlorophenyl)-4- fluoro-6-[1-hydroxy-1-(1-methyl-1H- pyrazol-4-yl)ethyl]-3-[(1- hydroxycyclopropyl)methoxy]-2,3- dihydro-1H-isoindol-1-one::US11236047, Example 409

SMILES Cn1cc(cn1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)c[n+]3[O-])[C@](OCC3(O)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=XFMUFTRUWONRPH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535453   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535453BDBM535453((3R)-2-[(5-chloro-1-oxo-1lambda5-pyridin-2- yl)met...)
Affinity DataIC50: 1.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent