BDBM535724 US11236047, Example 398::US20230338337, Compound 398

SMILES CC(O)(C1CCS(=O)(=O)CC1)c1cc2C(=O)N(Cc3ncc(Cl)cn3)[C@](OCC3(O)CC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=UQSZGPZMUWVMKS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535724   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 535724BDBM535724(US11236047, Example 398 | US20230338337, Compound ...)
Affinity DataIC50: 2.30nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 535724BDBM535724(US11236047, Example 398 | US20230338337, Compound ...)
Affinity DataIC50: 2.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent